Inhibition of IGF-1R-Dependent PI3K Activation Sensitizes Colon Cancer Cells Specifically to DR5-Mediated Apoptosis But Not to rhTRAIL

Background: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) initiates apoptosis in tumor cells upon binding to its cognate agonistic receptors, death receptors 4 and 5 (DR4 and DR5). The activity of the insulin-like growth factor 1 (IGF-1) survival pathway is often increased in cance...

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Detalles Bibliográficos
Autores principales: Pennarun, Bodvael, Kleibeuker, Jan H., Oenema, Tjitske, Stegehuis, Janet H., de Vries, Elisabeth G.E., de Jong, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2010
Materias:
Other
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605769/
https://www.ncbi.nlm.nih.gov/pubmed/20978316
http://dx.doi.org/10.3233/ACP-CLO-2010-0549

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605769/
https://www.ncbi.nlm.nih.gov/pubmed/20978316
http://dx.doi.org/10.3233/ACP-CLO-2010-0549

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