Cargando…

Inhibition of IGF-1R-Dependent PI3K Activation Sensitizes Colon Cancer Cells Specifically to DR5-Mediated Apoptosis But Not to rhTRAIL

Background: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) initiates apoptosis in tumor cells upon binding to its cognate agonistic receptors, death receptors 4 and 5 (DR4 and DR5). The activity of the insulin-like growth factor 1 (IGF-1) survival pathway is often increased in cance...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pennarun, Bodvael, Kleibeuker, Jan H., Oenema, Tjitske, Stegehuis, Janet H., de Vries, Elisabeth G.E., de Jong, Steven
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2010
Materias:	Other
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605769/ https://www.ncbi.nlm.nih.gov/pubmed/20978316 http://dx.doi.org/10.3233/ACP-CLO-2010-0549

Ejemplares similares

Targeting AML through DR4 with a novel variant of rhTRAIL
por: Szegezdi, Eva, et al.
Publicado: (2011)

Modulation of TRAIL resistance in colon carcinoma cells: Different contributions of DR4 and DR5
por: van Geelen, Caroline MM, et al.
Publicado: (2011)

Nutlin-3 preferentially sensitises wild-type p53-expressing cancer cells to DR5-selective TRAIL over rhTRAIL
por: Meijer, A, et al.
Publicado: (2013)

Drug-induced caspase 8 upregulation sensitises cisplatin-resistant ovarian carcinoma cells to rhTRAIL-induced apoptosis
por: Duiker, E W, et al.
Publicado: (2011)

Combined effect of the pro-apoptotic rhTRAIL protein and HSV-1 virus in head and neck cancer cell lines
por: Bravo Perina, Lucas, et al.
Publicado: (2023)

Preclinical screening of histone deacetylase inhibitors combined with ABT-737, rhTRAIL/MD5-1 or 5-azacytidine using syngeneic Vk*MYC multiple myeloma
por: Matthews, G M, et al.
Publicado: (2013)

A novel caspase 8 selective small molecule potentiates TRAIL-induced cell death
por: Bucur, Octavian, et al.
Publicado: (2015)

Assessment of compatibility of rhIGF-1/rhIGFBP-3 with neonatal intravenous medications
por: Salamat-Miller, Nazila, et al.
Publicado: (2022)

rhIGF-1/rhIGFBP-3 in Preterm Infants: A Phase 2 Randomized Controlled Trial
por: Ley, David, et al.
Publicado: (2018)

Differential modulation of the TRAIL receptors and the CD95 receptor in colon carcinoma cell lines
por: van Geelen, C M M, et al.
Publicado: (2003)

Pilot dose-ranging of rhIGF-1/rhIGFBP-3 in a preterm lamb model of evolving bronchopulmonary dysplasia
por: Albertine, Kurt H., et al.
Publicado: (2023)

Combination of Bortezomib and Mitotic Inhibitors Down-Modulate Bcr-Abl and Efficiently Eliminates Tyrosine-Kinase Inhibitor Sensitive and Resistant Bcr-Abl-Positive Leukemic Cells
por: Bucur, Octavian, et al.
Publicado: (2013)

Antagonists of growth hormone-releasing hormone (GH-RH) inhibit IGF-II production and growth of HT-29 human colon cancers
por: Szepeshazi, K, et al.
Publicado: (2000)

The Combination of TRAIL Treatment and Cancer Cell Selective Expression of TRAIL-Death Receptor DR4 Induces Cell Death in TRAIL-Resistant Cancer Cells
por: Choi, Eunah, et al.
Publicado: (2006)

rhIGF-1 Therapy: A Silver Bullet for Bronchopulmonary Dysplasia Prevention?
por: Plosa, Erin J., et al.
Publicado: (2020)

Effectiveness and safety of rhIGF1 therapy in patients with or without Laron syndrome
por: Bang, Peter, et al.
Publicado: (2020)

Genetically Modified DR5-Specific TRAIL Variant DR5-B Revealed Dual Antitumor and Protumoral Effect in Colon Cancer Xenografts and an Improved Pharmacokinetic Profile
por: Yagolovich, Anne V., et al.
Publicado: (2020)

rhIGF-1 Therapy for Growth Failure and IGF-1 Deficiency in Congenital Disorder of Glycosylation Ia (PMM2 Deficiency)
por: Miller, Bradley S., et al.
Publicado: (2013)

Diagnosis of Idiopathic GHD in Children Based on Response to rhGH Treatment: The Importance of GH Provocative Tests and IGF-1
por: Felício, João Soares, et al.
Publicado: (2019)

Randomized Control Trial of Postnatal rhIGF-1/rhIGFBP-3 Replacement in Preterm Infants: Post-hoc Analysis of Its Effect on Brain Injury
por: Horsch, Sandra, et al.
Publicado: (2020)

Expression of TRAIL-R2 (DR5) on fibroblasts from synovial fluid of rheumatoid arthritis
por: Miranda, E, et al.
Publicado: (2004)

rhIGF-1/BP3 Preserves Lung Growth and Prevents Pulmonary Hypertension in Experimental Bronchopulmonary Dysplasia
por: Seedorf, Gregory, et al.
Publicado: (2020)

TRAIL/S-layer/graphene quantum dot nanohybrid enhanced stability and anticancer activity of TRAIL on colon cancer cells
por: Lotfollahzadeh, Shima, et al.
Publicado: (2022)

Ginsenoside compound K sensitizes human colon cancer cells to TRAIL-induced apoptosis via autophagy-dependent and -independent DR5 upregulation
por: Chen, Lei, et al.
Publicado: (2016)

Activation of TRAIL‐DR5 pathway promotes sensorineural degeneration in the inner ear
por: Kao, Shyan‐Yuan, et al.
Publicado: (2016)

Cannabidiol Enhances the Therapeutic Effects of TRAIL by Upregulating DR5 in Colorectal Cancer
por: Kim, Jung Lim, et al.
Publicado: (2019)

Salirasib sensitizes hepatocarcinoma cells to TRAIL-induced apoptosis through DR5 and survivin-dependent mechanisms
por: Charette, N, et al.
Publicado: (2013)

DR5 Up-Regulation Induced by Dichloroacetate Sensitizes Tumor Cells to Lipid Nanoparticles Decorated with TRAIL
por: Marco-Brualla, Joaquín, et al.
Publicado: (2023)

Combination of TRAIL with Bortezomib Shifted Apoptotic Signaling from DR4 to DR5 Death Receptor by Selective Internalization and Degradation of DR4
por: Bychkov, Maxim L., et al.
Publicado: (2014)

Epithelial cell proliferation in the sigmoid colon of patients with adenomatous polyps increases during oral calcium supplementation.
por: Kleibeuker, J. H., et al.
Publicado: (1993)

Azithromycin enhances anticancer activity of TRAIL by inhibiting autophagy and up-regulating the protein levels of DR4/5 in colon cancer cells in vitro and in vivo
por: Qiao, Xinran, et al.
Publicado: (2018)

A Novel Role of IGF1 in Apo2L/TRAIL-Mediated Apoptosis of Ewing Tumor Cells
por: van Valen, Frans, et al.
Publicado: (2012)

TRAIL DR5-CTSB crosstalk participates in breast cancer autophagy initiated by SAHA
por: Han, Han, et al.
Publicado: (2017)

Potentiation of TRAIL-Induced Apoptosis in TRAIL-Resistant Cholangiocarcinoma Cells by Curcumin through the Induction of DR5 Membrane Localization and Disruption of the Anti-Apoptotic Complex DR5/DDX3/GSK3β
por: Visitnonthachai, Daranee, et al.
Publicado: (2023)

Heightened JNK Activation and Reduced XIAP Levels Promote TRAIL and Sunitinib-Mediated Apoptosis in Colon Cancer Models
por: Mahalingam, Devalingam, et al.
Publicado: (2019)

TRAIL Induces Nuclear Translocation and Chromatin Localization of TRAIL Death Receptors
por: Mert, Ufuk, et al.
Publicado: (2019)

Role of phloretin as a sensitizer to TRAIL-induced apoptosis in colon cancer
por: Kim, Jung-Lim, et al.
Publicado: (2022)

High susceptibility of metastatic cells derived from human prostate and colon cancer cells to TRAIL and sensitization of TRAIL-insensitive primary cells to TRAIL by 4,5-dimethoxy-2-nitrobenzaldehyde
por: Kim, Hak-Bong, et al.
Publicado: (2011)

Trailing TRAIL Resistance: Novel Targets for TRAIL Sensitization in Cancer Cells
por: Trivedi, Rachana, et al.
Publicado: (2015)

Dissecting the roles of DR4, DR5 and c-FLIP in the regulation of Geranylgeranyltransferase I inhibition-mediated augmentation of TRAIL-induced apoptosis
por: Chen, Shuzhen, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_o2c3sllj644jhijrm4k0ftrsp7