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Why sildenafil and sildenafil citrate monohydrate crystals are not stable?

Sildenafil citrate was crystallized by various techniques aiming to determine the behavior and factors affecting the crystal growth. There are only 2 types of sildenafil obtaining from crystallization: sildenafil (1) and sildenafil citrate monohydrate (2). The used techniques were (i) crystallizatio...

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Detalles Bibliográficos
Autores principales: Sawatdee, Somchai, Pakawatchai, Chaveng, Nitichai, Kwanjai, Srichana, Teerapol, Phetmung, Hirihattaya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605910/
https://www.ncbi.nlm.nih.gov/pubmed/26594116
http://dx.doi.org/10.1016/j.jsps.2015.01.019