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Systematic Analysis of the Associations between Adverse Drug Reactions and Pathways

Adverse drug reactions (ADRs) are responsible for drug candidate failure during clinical trials. It is crucial to investigate biological pathways contributing to ADRs. Here, we applied a large-scale analysis to identify overrepresented ADR-pathway combinations through merging clinical phenotypic dat...

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Detalles Bibliográficos
Autores principales: Chen, Xiaowen, Wang, Yanqiu, Wang, Pingping, Lian, Baofeng, Li, Chunquan, Wang, Jing, Li, Xia, Jiang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606217/
https://www.ncbi.nlm.nih.gov/pubmed/26495310
http://dx.doi.org/10.1155/2015/670949