Lysosomal and phagocytic activity is increased in astrocytes during disease progression in the SOD1 (G93A) mouse model of amyotrophic lateral sclerosis

Astrocytes are key players in the progression of amyotrophic lateral sclerosis (ALS). Previously, gene expression profiling of astrocytes from the pre-symptomatic stage of the SOD1(G93A) model of ALS has revealed reduced lactate metabolism and altered trophic support. Here, we have performed microar...

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Detalles Bibliográficos
Autores principales: Baker, David J., Blackburn, Daniel J., Keatinge, Marcus, Sokhi, Dilraj, Viskaitis, Paulius, Heath, Paul R., Ferraiuolo, Laura, Kirby, Janine, Shaw, Pamela J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606544/
https://www.ncbi.nlm.nih.gov/pubmed/26528138
http://dx.doi.org/10.3389/fncel.2015.00410

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606544/
https://www.ncbi.nlm.nih.gov/pubmed/26528138
http://dx.doi.org/10.3389/fncel.2015.00410

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