Lysosomal and phagocytic activity is increased in astrocytes during disease progression in the SOD1 (G93A) mouse model of amyotrophic lateral sclerosis

Astrocytes are key players in the progression of amyotrophic lateral sclerosis (ALS). Previously, gene expression profiling of astrocytes from the pre-symptomatic stage of the SOD1(G93A) model of ALS has revealed reduced lactate metabolism and altered trophic support. Here, we have performed microar...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Baker, David J., Blackburn, Daniel J., Keatinge, Marcus, Sokhi, Dilraj, Viskaitis, Paulius, Heath, Paul R., Ferraiuolo, Laura, Kirby, Janine, Shaw, Pamela J.
Format: Online Artikel Text
Sprache:English
Veröffentlicht: Frontiers Media S.A. 2015
Schlagworte:
Neuroscience
Online Zugang:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606544/
https://www.ncbi.nlm.nih.gov/pubmed/26528138
http://dx.doi.org/10.3389/fncel.2015.00410

Online

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606544/
https://www.ncbi.nlm.nih.gov/pubmed/26528138
http://dx.doi.org/10.3389/fncel.2015.00410

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