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Lysosomal and phagocytic activity is increased in astrocytes during disease progression in the SOD1 (G93A) mouse model of amyotrophic lateral sclerosis

Astrocytes are key players in the progression of amyotrophic lateral sclerosis (ALS). Previously, gene expression profiling of astrocytes from the pre-symptomatic stage of the SOD1(G93A) model of ALS has revealed reduced lactate metabolism and altered trophic support. Here, we have performed microar...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों: Baker, David J., Blackburn, Daniel J., Keatinge, Marcus, Sokhi, Dilraj, Viskaitis, Paulius, Heath, Paul R., Ferraiuolo, Laura, Kirby, Janine, Shaw, Pamela J.
स्वरूप: Online लेख मूलपाठ
भाषा:English
प्रकाशित: Frontiers Media S.A. 2015
विषय:
ऑनलाइन पहुंच:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606544/
https://www.ncbi.nlm.nih.gov/pubmed/26528138
http://dx.doi.org/10.3389/fncel.2015.00410