Lysosomal and phagocytic activity is increased in astrocytes during disease progression in the SOD1 (G93A) mouse model of amyotrophic lateral sclerosis

Astrocytes are key players in the progression of amyotrophic lateral sclerosis (ALS). Previously, gene expression profiling of astrocytes from the pre-symptomatic stage of the SOD1(G93A) model of ALS has revealed reduced lactate metabolism and altered trophic support. Here, we have performed microar...

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Bibliografske podrobnosti
Autores principales: Baker, David J., Blackburn, Daniel J., Keatinge, Marcus, Sokhi, Dilraj, Viskaitis, Paulius, Heath, Paul R., Ferraiuolo, Laura, Kirby, Janine, Shaw, Pamela J.
Format: Online Artículo Texto
Jezik:English
Izdano: Frontiers Media S.A. 2015
Teme:
Neuroscience
Online dostop:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606544/
https://www.ncbi.nlm.nih.gov/pubmed/26528138
http://dx.doi.org/10.3389/fncel.2015.00410

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606544/
https://www.ncbi.nlm.nih.gov/pubmed/26528138
http://dx.doi.org/10.3389/fncel.2015.00410

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