Mitochondrial DNA Polymerase POLG1 Disease Mutations and Germline Variants Promote Tumorigenic Properties

Germline mutations in mitochondrial DNA polymerase gamma (POLG1) induce mitochondrial DNA (mtDNA) mutations, depletion, and decrease oxidative phosphorylation. Earlier, we identified somatic mutations in POLG1 and the contribution of these mutations in human cancer. However, a role for germline vari...

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Detalles Bibliográficos
Autores principales: Singh, Bhupendra, Owens, Kjerstin M., Bajpai, Prachi, Desouki, Mohamed Mokhtar, Srinivasasainagendra, Vinodh, Tiwari, Hemant K., Singh, Keshav K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607296/
https://www.ncbi.nlm.nih.gov/pubmed/26468652
http://dx.doi.org/10.1371/journal.pone.0139846

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607296/
https://www.ncbi.nlm.nih.gov/pubmed/26468652
http://dx.doi.org/10.1371/journal.pone.0139846

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