CCR2(+) Inflammatory Dendritic Cells and Translocation of Antigen by Type III Secretion Are Required for the Exceptionally Large CD8(+) T Cell Response to the Protective YopE(69-77) Epitope during Yersinia Infection

During Yersinia pseudotuberculosis infection of C57BL/6 mice, an exceptionally large CD8(+) T cell response to a protective epitope in the type III secretion system effector YopE is produced. At the peak of the response, up to 50% of splenic CD8(+) T cells recognize the epitope YopE(69-77). The feat...

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Detalles Bibliográficos
Autores principales: Zhang, Yue, Tam, Jason W., Mena, Patricio, van der Velden, Adrianus W. M., Bliska, James B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607306/
https://www.ncbi.nlm.nih.gov/pubmed/26468944
http://dx.doi.org/10.1371/journal.ppat.1005167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607306/
https://www.ncbi.nlm.nih.gov/pubmed/26468944
http://dx.doi.org/10.1371/journal.ppat.1005167

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