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CCR2(+) Inflammatory Dendritic Cells and Translocation of Antigen by Type III Secretion Are Required for the Exceptionally Large CD8(+) T Cell Response to the Protective YopE(69-77) Epitope during Yersinia Infection
During Yersinia pseudotuberculosis infection of C57BL/6 mice, an exceptionally large CD8(+) T cell response to a protective epitope in the type III secretion system effector YopE is produced. At the peak of the response, up to 50% of splenic CD8(+) T cells recognize the epitope YopE(69-77). The feat...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607306/ https://www.ncbi.nlm.nih.gov/pubmed/26468944 http://dx.doi.org/10.1371/journal.ppat.1005167 |