Architecture of the Synaptotagmin-SNARE Machinery for Neuronal Exocytosis

Synaptotagmin-1 and neuronal SNARE proteins play key roles in evoked synchronous neurotransmitter release. However, it is unknown how they cooperate to trigger synaptic vesicle fusion. Here we report atomic-resolution crystal structures of Ca(2+)- and Mg(2+)-bound complexes between synaptotagmin-1 a...

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Detalles Bibliográficos
Autores principales: Zhou, Qiangjun, Lai, Ying, Bacaj, Taulant, Zhao, Minglei, Lyubimov, Artem Y., Uervirojnangkoorn, Monarin, Zeldin, Oliver B., Brewster, Aaron S., Sauter, Nicholas K., Cohen, Aina E., Soltis, S. Michael, Alonso-Mori, Roberto, Chollet, Matthieu, Lemke, Henrik T., Pfuetzner, Richard A., Choi, Ucheor B., Weis, William I., Diao, Jiajie, Südhof, Thomas C., Brunger, Axel T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607316/
https://www.ncbi.nlm.nih.gov/pubmed/26280336
http://dx.doi.org/10.1038/nature14975

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607316/
https://www.ncbi.nlm.nih.gov/pubmed/26280336
http://dx.doi.org/10.1038/nature14975

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