Increased Cortical Inhibition in Autism-Linked Neuroligin-3R451C Mice Is Due in Part to Loss of Endocannabinoid Signaling

A single, maternally inherited, X-linked point mutation leading to an arginine to cysteine substitution at amino acid 451 (R451C) of Neuroligin 3 (NLGN3(R451C)) is a likely cause of autism in two brothers. Knockin mice expressing the Nlgn3(R451C) mutation in place of wild-type Nlgn3 demonstrate incr...

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Detalles Bibliográficos
Autores principales: Speed, Haley E., Masiulis, Irene, Gibson, Jay R., Powell, Craig M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607423/
https://www.ncbi.nlm.nih.gov/pubmed/26469287
http://dx.doi.org/10.1371/journal.pone.0140638

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607423/
https://www.ncbi.nlm.nih.gov/pubmed/26469287
http://dx.doi.org/10.1371/journal.pone.0140638

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