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Increased Cortical Inhibition in Autism-Linked Neuroligin-3R451C Mice Is Due in Part to Loss of Endocannabinoid Signaling
A single, maternally inherited, X-linked point mutation leading to an arginine to cysteine substitution at amino acid 451 (R451C) of Neuroligin 3 (NLGN3(R451C)) is a likely cause of autism in two brothers. Knockin mice expressing the Nlgn3(R451C) mutation in place of wild-type Nlgn3 demonstrate incr...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607423/ https://www.ncbi.nlm.nih.gov/pubmed/26469287 http://dx.doi.org/10.1371/journal.pone.0140638 |