Anti-α4 Integrin Antibody Blocks Monocyte/Macrophage Traffic to the Heart and Decreases Cardiac Pathology in a SIV Infection Model of AIDS

BACKGROUND: Cardiovascular disease (CVD), myocarditis and fibrosis are comorbidities of HIV(+) individuals on durable antiretroviral therapy (ART). Although mechanisms for these vary, monocytes/macrophages are increasingly demonstrated to be key players. METHODS AND RESULTS: We directly blocked mono...

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Detalles Bibliográficos
Autores principales: Walker, Joshua A, Beck, Graham A, Campbell, Jennifer H, Miller, Andrew D, Burdo, Tricia H, Williams, Kenneth C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608078/
https://www.ncbi.nlm.nih.gov/pubmed/26185285
http://dx.doi.org/10.1161/JAHA.115.001932

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608078/
https://www.ncbi.nlm.nih.gov/pubmed/26185285
http://dx.doi.org/10.1161/JAHA.115.001932

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