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High-level secretion of native recombinant human calreticulin in yeast

BACKGROUND: Calreticulin (CRT) resides in the endoplasmic reticulum (ER) and functions to chaperone proteins, ensuring proper folding, and intracellular Ca(2+) homeostasis. Emerging evidence shows that CRT is a multifunctional protein with significant roles in physiological and pathological processe...

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Detalles Bibliográficos
Autores principales: Čiplys, Evaldas, Žitkus, Eimantas, Gold, Leslie I., Daubriac, Julien, Pavlides, Savvas C., Højrup, Peter, Houen, Gunnar, Wang, Wen-An, Michalak, Marek, Slibinskas, Rimantas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608220/
https://www.ncbi.nlm.nih.gov/pubmed/26471510
http://dx.doi.org/10.1186/s12934-015-0356-8