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Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality
Replicative stress during embryonic development influences ageing and predisposition to disease in adults. A protective mechanism against replicative stress is provided by the licensing of thousands of origins in G1 that are not necessarily activated in the subsequent S-phase. These ‘dormant' o...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Pub. Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608254/ https://www.ncbi.nlm.nih.gov/pubmed/26456157 http://dx.doi.org/10.1038/ncomms9548 |