Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality

Replicative stress during embryonic development influences ageing and predisposition to disease in adults. A protective mechanism against replicative stress is provided by the licensing of thousands of origins in G1 that are not necessarily activated in the subsequent S-phase. These ‘dormant' o...

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Detalles Bibliográficos
Autores principales: Alvarez, Silvia, Díaz, Marcos, Flach, Johanna, Rodriguez-Acebes, Sara, López-Contreras, Andrés J., Martínez, Dolores, Cañamero, Marta, Fernández-Capetillo, Oscar, Isern, Joan, Passegué, Emmanuelle, Méndez, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608254/
https://www.ncbi.nlm.nih.gov/pubmed/26456157
http://dx.doi.org/10.1038/ncomms9548

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608254/
https://www.ncbi.nlm.nih.gov/pubmed/26456157
http://dx.doi.org/10.1038/ncomms9548

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