Autophagy maintains the metabolism and function of young and old (hematopoietic) stem cells

With age, hematopoietic stem cells (HSCs) lose their ability to regenerate the blood system, and promote disease development. Autophagy is associated with health and longevity, and is critical for protecting HSCs from metabolic stress. Here, we show that loss of autophagy in HSCs causes accumulation...

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Detalles Bibliográficos
Autores principales: Ho, Theodore T., Warr, Matthew R., Adelman, Emmalee R., Lansinger, Olivia M., Flach, Johanna, Verovskaya, Evgenia V., Figueroa, Maria E., Passegué, Emmanuelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344718/
https://www.ncbi.nlm.nih.gov/pubmed/28241143
http://dx.doi.org/10.1038/nature21388

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344718/
https://www.ncbi.nlm.nih.gov/pubmed/28241143
http://dx.doi.org/10.1038/nature21388

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