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ATP binding to neighbouring subunits and intersubunit allosteric coupling underlie proteasomal ATPase function

The primary functions of the proteasome are driven by a highly allosteric ATPase complex. ATP binding to only two subunits in this hexameric complex triggers substrate binding, ATPase–20S association and 20S gate opening. However, it is unclear how ATP binding and hydrolysis spatially and temporally...

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Detalles Bibliográficos
Autores principales: Kim, Young-Chan, Snoberger, Aaron, Schupp, Jane, Smith, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608255/
https://www.ncbi.nlm.nih.gov/pubmed/26465836
http://dx.doi.org/10.1038/ncomms9520