Physiological modulation of BiP activity by trans-protomer engagement of the interdomain linker

DnaK/Hsp70 chaperones form oligomers of poorly understood structure and functional significance. Site-specific proteolysis and crosslinking were used to probe the architecture of oligomers formed by the endoplasmic reticulum (ER) Hsp70, BiP. These were found to consist of adjacent protomers engaging...

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Detalles Bibliográficos
Autores principales: Preissler, Steffen, Chambers, Joseph E, Crespillo-Casado, Ana, Avezov, Edward, Miranda, Elena, Perez, Juan, Hendershot, Linda M, Harding, Heather P, Ron, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608358/
https://www.ncbi.nlm.nih.gov/pubmed/26473973
http://dx.doi.org/10.7554/eLife.08961

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608358/
https://www.ncbi.nlm.nih.gov/pubmed/26473973
http://dx.doi.org/10.7554/eLife.08961

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