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Synthesis, Characterization, and Biological Evaluation of a Dual-Action Ligand Targeting α(v)β(3) Integrin and VEGF Receptors**
A dual-action ligand targeting both integrin α(V)β(3) and vascular endothelial growth factor receptors (VEGFRs), was synthesized via conjugation of a cyclic peptidomimetic α(V)β(3) Arg-Gly-Asp (RGD) ligand with a decapentapeptide. The latter was obtained from a known VEGFR antagonist by acetylation...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608532/ https://www.ncbi.nlm.nih.gov/pubmed/26491644 http://dx.doi.org/10.1002/open.201500062 |