Expression Quantitative Trait Loci Information Improves Predictive Modeling of Disease Relevance of Non-Coding Genetic Variation

Disease-associated loci identified through genome-wide association studies (GWAS) frequently localize to non-coding sequence. We and others have demonstrated strong enrichment of such single nucleotide polymorphisms (SNPs) for expression quantitative trait loci (eQTLs), supporting an important role...

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Detalles Bibliográficos
Autores principales: Croteau-Chonka, Damien C., Rogers, Angela J., Raj, Towfique, McGeachie, Michael J., Qiu, Weiliang, Ziniti, John P., Stubbs, Benjamin J., Liang, Liming, Martinez, Fernando D., Strunk, Robert C., Lemanske, Robert F., Liu, Andrew H., Stranger, Barbara E., Carey, Vincent J., Raby, Benjamin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608673/
https://www.ncbi.nlm.nih.gov/pubmed/26474488
http://dx.doi.org/10.1371/journal.pone.0140758

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608673/
https://www.ncbi.nlm.nih.gov/pubmed/26474488
http://dx.doi.org/10.1371/journal.pone.0140758

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