Factor VIII Is Synthesized in Human Endothelial Cells, Packaged in Weibel-Palade Bodies and Secreted Bound to ULVWF Strings

The cellular synthesis site and ensuing storage location for human factor VIII (FVIII), the coagulation protein deficient in hemophilia A, has been elusive. FVIII stability and half-life is dependent on non-covalent complex formation with von Willebrand factor (VWF) to avoid proteolysis and clearanc...

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Detalles Bibliográficos
Autores principales: Turner, Nancy A., Moake, Joel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608722/
https://www.ncbi.nlm.nih.gov/pubmed/26473492
http://dx.doi.org/10.1371/journal.pone.0140740

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608722/
https://www.ncbi.nlm.nih.gov/pubmed/26473492
http://dx.doi.org/10.1371/journal.pone.0140740

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