Cargando…

Factor VIII Is Synthesized in Human Endothelial Cells, Packaged in Weibel-Palade Bodies and Secreted Bound to ULVWF Strings

The cellular synthesis site and ensuing storage location for human factor VIII (FVIII), the coagulation protein deficient in hemophilia A, has been elusive. FVIII stability and half-life is dependent on non-covalent complex formation with von Willebrand factor (VWF) to avoid proteolysis and clearanc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Turner, Nancy A., Moake, Joel L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608722/ https://www.ncbi.nlm.nih.gov/pubmed/26473492 http://dx.doi.org/10.1371/journal.pone.0140740

Ejemplares similares

Regulatory Components of the Alternative Complement Pathway in Endothelial Cell Cytoplasm, Factor H and Factor I, Are Not Packaged in Weibel-Palade Bodies
por: Turner, Nancy A., et al.
Publicado: (2015)

Quantitative analysis of Weibel-Palade bodies
por: Liu, Alice, et al.
Publicado: (2022)

Storage of Factor VIII Variants with Impaired von Willebrand Factor Binding in Weibel-Palade Bodies in Endothelial Cells
por: van den Biggelaar, Maartje, et al.
Publicado: (2011)

Rapid Secretion of Prestored Interleukin 8 from Weibel-Palade Bodies of Microvascular Endothelial Cells
por: Utgaard, Jon Olav, et al.
Publicado: (1998)

Endothelial cell activation, Weibel-Palade body secretion, and enhanced angiogenesis in severe COVID-19
por: Karampini, Ellie, et al.
Publicado: (2023)

Proximity proteomics of endothelial Weibel-Palade bodies identifies novel regulator of von Willebrand factor secretion
por: Holthenrich, Anna, et al.
Publicado: (2019)

Immunolocalization of von Willebrand protein in Weibel-Palade bodies of human endothelial cells
Publicado: (1982)

The Effect of Shiga Toxin on Weibel-Palade Bodies in Primary Human Endothelial Cells
por: Geelen, Joyce, et al.
Publicado: (2014)

Rab35 protein regulates evoked exocytosis of endothelial Weibel–Palade bodies
por: Biesemann, Anja, et al.
Publicado: (2017)

Acidification of endothelial Weibel-Palade bodies is mediated by the vacuolar-type H(+)-ATPase
por: Terglane, Julian, et al.
Publicado: (2022)

Weibel-Palade Body Localized Syntaxin-3 Modulates Von Willebrand Factor Secretion From Endothelial Cells
por: Schillemans, Maaike, et al.
Publicado: (2018)

Tuning the endothelial response: differential release of exocytic cargos from Weibel‐Palade bodies
por: Nightingale, T. D., et al.
Publicado: (2018)

Weibel Palade Bodies: Unique Secretory Organelles of Endothelial Cells that Control Blood Vessel Homeostasis
por: Naß, Johannes, et al.
Publicado: (2021)

Clathrin-mediated post-fusion membrane retrieval influences the exocytic mode of endothelial Weibel-Palade bodies
por: Stevenson, Nicola L., et al.
Publicado: (2017)

N-ethylmaleimide-sensitive factor siRNA inhibits the release of Weibel-Palade bodies in endothelial cells
por: Zhou, Yong, et al.
Publicado: (2016)

Exocytosis of Weibel–Palade bodies: how to unpack a vascular emergency kit
por: Schillemans, M., et al.
Publicado: (2018)

Endothelial Cell “Memory” of Inflammatory Stimulation: Human Venular Endothelial Cells Store Interleukin 8 in Weibel-Palade Bodies
por: Wolff, Barbara, et al.
Publicado: (1998)

Syntaxin 5 determines Weibel-Palade body size and von Willebrand factor secretion by controlling Golgi architecture
por: Kat, Marije, et al.
Publicado: (2022)

Plasma membrane phosphatidylinositol (4,5)-bisphosphate promotes Weibel–Palade body exocytosis
por: Nguyen, Tu Thi Ngoc, et al.
Publicado: (2020)

An AP-1/clathrin coat plays a novel and essential role in forming the Weibel-Palade bodies of endothelial cells
por: Lui-Roberts, Winnie W.Y., et al.
Publicado: (2005)

Characterisation of Weibel–Palade body fusion by amperometry in endothelial cells reveals fusion pore dynamics and the effect of cholesterol on exocytosis
por: Cookson, Emma A., et al.
Publicado: (2013)

Weibel-Palade body size modulates the adhesive activity of its von Willebrand Factor cargo in cultured endothelial cells
por: Ferraro, Francesco, et al.
Publicado: (2016)

Weibel-Palade body exocytosis as a therapeutic target to improve hemodynamics in Gram-positive sepsis
por: Lee, JY, et al.
Publicado: (2012)

Differential Cargo Mobilisation within Weibel-Palade Bodies after Transient Fusion with the Plasma Membrane
por: Kiskin, Nikolai I., et al.
Publicado: (2014)

Interaction between MyRIP and the actin cytoskeleton regulates Weibel–Palade body trafficking and exocytosis
por: Conte, Ianina L., et al.
Publicado: (2016)

Towards the imaging of Weibel–Palade body biogenesis by serial block face-scanning electron microscopy
por: Mourik, MJ, et al.
Publicado: (2015)

Erratum: Weibel-Palade body size modulates the adhesive activity of its von Willebrand Factor cargo in cultured endothelial cells
por: Ferraro, Francesco, et al.
Publicado: (2016)

HPS6 Regulates the Biogenesis of Weibel–Palade Body in Endothelial Cells Through Trafficking v-ATPase to Its Limiting Membrane
por: Lu, Jiran, et al.
Publicado: (2022)

Inactivation of Cerebral Cavernous Malformation Genes Results in Accumulation of von Willebrand Factor and Redistribution of Weibel-Palade Bodies in Endothelial Cells
por: Much, Christiane D., et al.
Publicado: (2021)

Actomyosin II contractility expels von Willebrand factor from Weibel–Palade bodies during exocytosis
por: Nightingale, Thomas D., et al.
Publicado: (2011)

Heat-inactivated Factor B inhibits alternative pathway fluid-phase activation and convertase formation on endothelial cell-secreted ultra-large von Willebrand factor strings
por: Turner, Nancy A., et al.
Publicado: (2023)

Mutations in Neurobeachin-like 2 do not impact Weibel-Palade body biogenesis and von Willebrand factor secretion in gray platelet syndrome Endothelial Colony Forming Cells
por: Kat, Marije, et al.
Publicado: (2023)

Composition of the von Willebrand factor storage organelle (Weibel- Palade body) isolated from cultured human umbilical vein endothelial cells
Publicado: (1987)

Sphingosine-1-Phosphate Receptor 3 Mediates Sphingosine-1-Phosphate Induced Release of Weibel-Palade Bodies from Endothelial Cells
por: van Hooren, Kathinka W. E. M., et al.
Publicado: (2014)

Type II PI4-kinases control Weibel-Palade body biogenesis and von Willebrand factor structure in human endothelial cells
por: Lopes da Silva, Mafalda, et al.
Publicado: (2016)

APOLD1 loss causes endothelial dysfunction involving cell junctions, cytoskeletal architecture, and Weibel-Palade bodies, while disrupting hemostasis
por: Stritt, Simon, et al.
Publicado: (2022)

Temperature-Dependence of Weibel-Palade Body Exocytosis and Cell Surface Dispersal of von Willebrand Factor and Its Propolypeptide
por: Hewlett, Lindsay, et al.
Publicado: (2011)

Sec22b determines Weibel-Palade body length by controlling anterograde endoplasmic reticulum-Golgi transport
por: Karampini, Ellie, et al.
Publicado: (2020)

Shrinking Weibel‐Palade bodies prevents high platelet recruitment in assays using thrombotic thrombocytopenic purpura plasma
por: Patella, Francesca, et al.
Publicado: (2021)

GDP/GTP exchange factor MADD drives activation and recruitment of secretory Rab GTPases to Weibel-Palade bodies
por: Kat, Marije, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_hvce7bva7pi0jit0s8lp50ijmg