A Phenomic Scan of the Norfolk Island Genetic Isolate Identifies a Major Pleiotropic Effect Locus Associated with Metabolic and Renal Disorder Markers

Multiphenotype genome-wide association studies (GWAS) may reveal pleiotropic genes, which would remain undetected using single phenotype analyses. Analysis of large pedigrees offers the added advantage of more accurately assessing trait heritability, which can help prioritise genetically influenced...

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Detalles Bibliográficos
Autores principales: Benton, Miles C., Lea, Rodney A., Macartney-Coxson, Donia, Hanna, Michelle, Eccles, David A., Carless, Melanie A., Chambers, Geoffrey K., Bellis, Claire, Goring, Harald H., Curran, Joanne E., Harper, Jacquie L., Gibson, Gregory, Blangero, John, Griffiths, Lyn R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608754/
https://www.ncbi.nlm.nih.gov/pubmed/26474483
http://dx.doi.org/10.1371/journal.pgen.1005593

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608754/
https://www.ncbi.nlm.nih.gov/pubmed/26474483
http://dx.doi.org/10.1371/journal.pgen.1005593

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