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Palmitoylation of the Na/Ca exchanger cytoplasmic loop controls its inactivation and internalization during stress signaling

The electrogenic Na/Ca exchanger (NCX) mediates bidirectional Ca movements that are highly sensitive to changes of Na gradients in many cells. NCX1 is implicated in the pathogenesis of heart failure and a number of cardiac arrhythmias. We measured NCX1 palmitoylation using resin-assisted capture, th...

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Detalles Bibliográficos
Autores principales: Reilly, Louise, Howie, Jacqueline, Wypijewski, Krzysztof, Ashford, Michael L. J., Hilgemann, Donald W., Fuller, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Federation of American Societies for Experimental Biology 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608915/
https://www.ncbi.nlm.nih.gov/pubmed/26174834
http://dx.doi.org/10.1096/fj.15-276493