Intravenous injection of microvesicle-delivery miR-130b alleviates high-fat diet-induced obesity in C57BL/6 mice through translational repression of PPAR-γ

BACKGROUND: We have shown previously that microvesicle (MV)-delivered miR-130b (miR-130b-MV) is able to target PPAR-γ and subsequently reduce the lipid accumulation in vitro. However, the in vivo effect of miR-130b on fat deposition and glucose homeostasis remains unknown. RESULTS: Three-week-old C5...

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Detalles Bibliográficos
Autores principales: Pan, Shifeng, Yang, Xiaojing, Jia, Yimin, Li, Yue, Chen, Rirong, Wang, Min, Cai, Demin, Zhao, Ruqian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609132/
https://www.ncbi.nlm.nih.gov/pubmed/26475357
http://dx.doi.org/10.1186/s12929-015-0193-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609132/
https://www.ncbi.nlm.nih.gov/pubmed/26475357
http://dx.doi.org/10.1186/s12929-015-0193-4

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