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Intravenous injection of microvesicle-delivery miR-130b alleviates high-fat diet-induced obesity in C57BL/6 mice through translational repression of PPAR-γ

BACKGROUND: We have shown previously that microvesicle (MV)-delivered miR-130b (miR-130b-MV) is able to target PPAR-γ and subsequently reduce the lipid accumulation in vitro. However, the in vivo effect of miR-130b on fat deposition and glucose homeostasis remains unknown. RESULTS: Three-week-old C5...

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Detalles Bibliográficos
Autores principales:	Pan, Shifeng, Yang, Xiaojing, Jia, Yimin, Li, Yue, Chen, Rirong, Wang, Min, Cai, Demin, Zhao, Ruqian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609132/ https://www.ncbi.nlm.nih.gov/pubmed/26475357 http://dx.doi.org/10.1186/s12929-015-0193-4

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