A Ubl/ubiquitin switch in the activation of Parkin

Mutations in Parkin and PINK1 cause an inherited early-onset form of Parkinson's disease. The two proteins function together in a mitochondrial quality control pathway whereby PINK1 accumulates on damaged mitochondria and activates Parkin to induce mitophagy. How PINK1 kinase activity releases...

Descripción completa

Detalles Bibliográficos
Autores principales: Sauvé, Véronique, Lilov, Asparouh, Seirafi, Marjan, Vranas, Marta, Rasool, Shafqat, Kozlov, Guennadi, Sprules, Tara, Wang, Jimin, Trempe, Jean-François, Gehring, Kalle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609182/
https://www.ncbi.nlm.nih.gov/pubmed/26254305
http://dx.doi.org/10.15252/embj.201592237

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609182/
https://www.ncbi.nlm.nih.gov/pubmed/26254305
http://dx.doi.org/10.15252/embj.201592237

Ejemplares similares