A Designed Angiopoietin-1 Variant, Dimeric CMP-Ang1 Activates Tie2 and Stimulates Angiogenesis and Vascular Stabilization in N-glycan Dependent Manner

Angiopoietin-1 (Ang1), a potential growth factor for therapeutic angiogenesis and vascular stabilization, is known to specifically cluster and activate Tie2 in high oligomeric forms, which is a unique and essential process in this ligand-receptor interaction. However, highly oligomeric native Ang1 a...

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Detalles Bibliográficos
Autores principales: Oh, Nuri, Kim, Kangsan, Jin Kim, Soo, Park, Intae, Lee, Jung-Eun, Suk Seo, Young, Joo An, Hyun, Min Kim, Ho, Young Koh, Gou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609988/
https://www.ncbi.nlm.nih.gov/pubmed/26478188
http://dx.doi.org/10.1038/srep15291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609988/
https://www.ncbi.nlm.nih.gov/pubmed/26478188
http://dx.doi.org/10.1038/srep15291

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