PARP1 Inhibitors: antitumor drug design

The poly (ADP-ribose) polymerase 1 (PARP1) enzyme is one of the promising molecular targets for the discovery of antitumor drugs. PARP1 is a common nuclear protein (1–2 million molecules per cell) serving as a “sensor” for DNA strand breaks. Increased PARP1 expression is sometimes observed in melano...

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Detalles Bibliográficos
Autores principales: Malyuchenko, N. V., Kotova, E. Yu., Kulaeva, O. I., Kirpichnikov, M. P., Studitskiy, V. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610162/
https://www.ncbi.nlm.nih.gov/pubmed/26483957

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610162/
https://www.ncbi.nlm.nih.gov/pubmed/26483957

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