The Use of Transcription Terminators to Generate Transgenic Lines of Chinese Hamster Ovary Cells (CHO) with Stable and High Level of Reporter Gene Expression

Mammalian cell lines are widely used to produce recombinant proteins. Stable transgenic cell lines usually contain many insertions of the expression vector in one genomic region. Transcription through transgene can be one of the reasons for target gene repression after prolonged cultivation of cell...

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Detalles Bibliográficos
Autores principales: Gasanov, N. B., Toshchakov, S. V., Georgiev, P. G., Maksimenko, O. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610167/
https://www.ncbi.nlm.nih.gov/pubmed/26483962

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610167/
https://www.ncbi.nlm.nih.gov/pubmed/26483962

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