5-Arylaminouracil Derivatives as Potential Dual-Action Agents

Several 5-aminouracil derivatives that have previously been shown to inhibit Mycobacterium tuberculosis growth at concentrations of 5–40 μg/mL are demonstrated to act also as noncompetitive non-nucleoside inhibitors of HIV-1 reverse transcriptase without causing toxicity in vitro (MT-4 cells) and ex...

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Autores principales: Matyugina, E. S., Novikov, M. S., Babkov, D. A., Valuev-Elliston, V. T., Vanpouille, C., Zicari, S., Corona, A., Tramontano, E., Margolis, L. B., Khandazhinskaya, A. L., Kochetkov, S. N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610172/
https://www.ncbi.nlm.nih.gov/pubmed/26483967
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author Matyugina, E. S.
Novikov, M. S.
Babkov, D. A.
Valuev-Elliston, V. T.
Vanpouille, C.
Zicari, S.
Corona, A.
Tramontano, E.
Margolis, L. B.
Khandazhinskaya, A. L.
Kochetkov, S. N.
author_facet Matyugina, E. S.
Novikov, M. S.
Babkov, D. A.
Valuev-Elliston, V. T.
Vanpouille, C.
Zicari, S.
Corona, A.
Tramontano, E.
Margolis, L. B.
Khandazhinskaya, A. L.
Kochetkov, S. N.
author_sort Matyugina, E. S.
collection PubMed
description Several 5-aminouracil derivatives that have previously been shown to inhibit Mycobacterium tuberculosis growth at concentrations of 5–40 μg/mL are demonstrated to act also as noncompetitive non-nucleoside inhibitors of HIV-1 reverse transcriptase without causing toxicity in vitro (MT-4 cells) and ex vivo (human tonsillar tissue).
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spelling pubmed-46101722015-10-19 5-Arylaminouracil Derivatives as Potential Dual-Action Agents Matyugina, E. S. Novikov, M. S. Babkov, D. A. Valuev-Elliston, V. T. Vanpouille, C. Zicari, S. Corona, A. Tramontano, E. Margolis, L. B. Khandazhinskaya, A. L. Kochetkov, S. N. Acta Naturae Research Article Several 5-aminouracil derivatives that have previously been shown to inhibit Mycobacterium tuberculosis growth at concentrations of 5–40 μg/mL are demonstrated to act also as noncompetitive non-nucleoside inhibitors of HIV-1 reverse transcriptase without causing toxicity in vitro (MT-4 cells) and ex vivo (human tonsillar tissue). A.I. Gordeyev 2015 /pmc/articles/PMC4610172/ /pubmed/26483967 Text en Copyright ® 2015 Park-media Ltd. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Matyugina, E. S.
Novikov, M. S.
Babkov, D. A.
Valuev-Elliston, V. T.
Vanpouille, C.
Zicari, S.
Corona, A.
Tramontano, E.
Margolis, L. B.
Khandazhinskaya, A. L.
Kochetkov, S. N.
5-Arylaminouracil Derivatives as Potential Dual-Action Agents
title 5-Arylaminouracil Derivatives as Potential Dual-Action Agents
title_full 5-Arylaminouracil Derivatives as Potential Dual-Action Agents
title_fullStr 5-Arylaminouracil Derivatives as Potential Dual-Action Agents
title_full_unstemmed 5-Arylaminouracil Derivatives as Potential Dual-Action Agents
title_short 5-Arylaminouracil Derivatives as Potential Dual-Action Agents
title_sort 5-arylaminouracil derivatives as potential dual-action agents
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610172/
https://www.ncbi.nlm.nih.gov/pubmed/26483967
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