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OTX2 exhibits cell-context-dependent effects on cellular and molecular properties of human embryonic neural precursors and medulloblastoma cells

Medulloblastoma (MB) is the most common malignant primary pediatric brain tumor and is currently divided into four subtypes based on different genomic alterations, gene expression profiles and response to treatment: WNT, Sonic Hedgehog (SHH), Group 3 and Group 4. This extensive heterogeneity has mad...

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Detalles Bibliográficos
Autores principales: Kaur, Ravinder, Aiken, Christopher, Morrison, Ludivine Coudière, Rao, Radhika, Del Bigio, Marc R., Rampalli, Shravanti, Werbowetski-Ogilvie, Tamra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610233/
https://www.ncbi.nlm.nih.gov/pubmed/26398939
http://dx.doi.org/10.1242/dmm.020594