From drug response profiling to target addiction scoring in cancer cell models

Deconvoluting the molecular target signals behind observed drug response phenotypes is an important part of phenotype-based drug discovery and repurposing efforts. We demonstrate here how our network-based deconvolution approach, named target addiction score (TAS), provides insights into the functio...

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Detalles Bibliográficos
Autores principales: Yadav, Bhagwan, Gopalacharyulu, Peddinti, Pemovska, Tea, Khan, Suleiman A., Szwajda, Agnieszka, Tang, Jing, Wennerberg, Krister, Aittokallio, Tero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2015
Materias:
Resource Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610238/
https://www.ncbi.nlm.nih.gov/pubmed/26438695
http://dx.doi.org/10.1242/dmm.021105

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610238/
https://www.ncbi.nlm.nih.gov/pubmed/26438695
http://dx.doi.org/10.1242/dmm.021105

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