Premature termination codons are recognized in the nucleus in a reading-frame-dependent manner

mRNAs containing premature termination codons (PTCs) are known to be degraded via nonsense-mediated mRNA decay (NMD). Unexpectedly, we found that mRNAs containing any type of PTCs (UAA, UAG, and UGA) are detained in the nucleus, whereas their wild-type counterparts are rapidly exported. This retenti...

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Detalles Bibliográficos
Autores principales: Shi, Min, Zhang, Heng, Wang, Lantian, Zhu, Changlan, Sheng, Ke, Du, Yanhua, Wang, Ke, Dias, Anusha, Chen, She, Whitman, Malcolm, Wang, Enduo, Reed, Robin, Cheng, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610414/
https://www.ncbi.nlm.nih.gov/pubmed/26491543
http://dx.doi.org/10.1038/celldisc.2015.1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610414/
https://www.ncbi.nlm.nih.gov/pubmed/26491543
http://dx.doi.org/10.1038/celldisc.2015.1

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