1α,25-dihydroxyvitamin D3 acts via transforming growth factor-β to up-regulate expression of immunosuppressive CD73 on human CD4(+) Foxp3(–) T cells

Vitamin D deficiency is associated with increased incidence and severity of various immune-mediated diseases. Active vitamin D (1α,25-dihydroxyvitamin D3; 1,25(OH)(2)D3) up-regulates CD4(+) T-cell expression of the purine ectonucleotidase CD39, a molecule that is associated with the generation of an...

Descripción completa

Detalles Bibliográficos
Autores principales: Mann, Elizabeth H, Chambers, Emma S, Chen, Yin-Huai, Richards, David F, Hawrylowicz, Catherine M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610631/
https://www.ncbi.nlm.nih.gov/pubmed/26251265
http://dx.doi.org/10.1111/imm.12519

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610631/
https://www.ncbi.nlm.nih.gov/pubmed/26251265
http://dx.doi.org/10.1111/imm.12519

Ejemplares similares