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1α,25-dihydroxyvitamin D3 acts via transforming growth factor-β to up-regulate expression of immunosuppressive CD73 on human CD4(+) Foxp3(–) T cells

Vitamin D deficiency is associated with increased incidence and severity of various immune-mediated diseases. Active vitamin D (1α,25-dihydroxyvitamin D3; 1,25(OH)(2)D3) up-regulates CD4(+) T-cell expression of the purine ectonucleotidase CD39, a molecule that is associated with the generation of an...

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Detalles Bibliográficos
Autores principales:	Mann, Elizabeth H, Chambers, Emma S, Chen, Yin-Huai, Richards, David F, Hawrylowicz, Catherine M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Ltd 2015
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610631/ https://www.ncbi.nlm.nih.gov/pubmed/26251265 http://dx.doi.org/10.1111/imm.12519

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