Cargando…
Development of PPAR-agonist GW0742 as antidiabetic drug: study in animals
BACKGROUND: The development of new drugs for the treatment of diabetes mellitus (DM) is critically important. Insulin resistance (IR) is one of the main problems associated with type-2 DM (T2DM) seen in clinics. GW0742, a selective peroxisome proliferator-activated receptor (PPAR)-δ agonist, has bee...
Autores principales: | Niu, Ho-Shan, Ku, Po-Ming, Niu, Chiang-Shan, Cheng, Juei-Tang, Lee, Kung-Shing |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610778/ https://www.ncbi.nlm.nih.gov/pubmed/26508837 http://dx.doi.org/10.2147/DDDT.S95045 |
Ejemplares similares
-
Effects of the PPAR-β/δ agonist GW0742 during resuscitated porcine septic shock
por: Wepler, Martin, et al.
Publicado: (2013) -
Context-dependent regulation of endothelial cell metabolism: differential effects of the PPARβ/δ agonist GW0742 and VEGF-A
por: Faulkner, Ashton, et al.
Publicado: (2020) -
The PPARβ/δAgonist GW0742 Relaxes Pulmonary Vessels and Limits Right Heart Hypertrophy in Rats with Hypoxia-Induced Pulmonary Hypertension
por: Harrington, Louise S., et al.
Publicado: (2010) -
Reduced expression of PPAR-β/δ limits the potential beneficial effects of GW0742 during septic shock in atherosclerotic swine
por: Bracht, H, et al.
Publicado: (2012) -
Erythropoietin ameliorates hyperglycemia in type 1-like diabetic rats
por: Niu, Ho-Shan, et al.
Publicado: (2016)