Paeoniflorin inhibits human glioma cells via STAT3 degradation by the ubiquitin–proteasome pathway

We investigated the underlying mechanism for the potent proapoptotic effect of paeoniflorin (PF) on human glioma cells in vitro, focusing on signal transducer and activator of transcription 3 (STAT3) signaling. Significant time- and dose-dependent apoptosis and inhibition of proliferation were obser...

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Detalles Bibliográficos
Autores principales: Nie, Xiao-hu, Ou-yang, Jia, Xing, Ying, Li, Dan-yan, Dong, Xing-yu, Liu, Ru-en, Xu, Ru-xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610779/
https://www.ncbi.nlm.nih.gov/pubmed/26508835
http://dx.doi.org/10.2147/DDDT.S93912

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610779/
https://www.ncbi.nlm.nih.gov/pubmed/26508835
http://dx.doi.org/10.2147/DDDT.S93912

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