Cargando…
Inducing Oncoprotein Degradation to Improve Targeted Cancer Therapy()
Over the past decade, inhibition of the kinase activities of oncogenic proteins using small molecules and antibodies has been a mainstay of our anticancer drug development effort, resulting in several Food and Drug Administration–approved cancer therapies. The clinical effectiveness of kinase-target...
Autores principales: | Ray, Dipankar, Cuneo, Kyle C., Rehemtulla, Alnawaz, Lawrence, Theodore S., Nyati, Mukesh K. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Neoplasia Press
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611070/ https://www.ncbi.nlm.nih.gov/pubmed/26476077 http://dx.doi.org/10.1016/j.neo.2015.08.008 |
Ejemplares similares
-
TGFBR2 mediated phosphorylation of BUB1 at Ser-318 is required for transforming growth factor-β signaling
por: Nyati, Shyam, et al.
Publicado: (2020) -
Budding uninhibited by benzimidazoles-1 (BUB1) regulates EGFR signaling by reducing EGFR internalization
por: Nyati, Shyam, et al.
Publicado: (2023) -
Differential protein stability of EGFR mutants determines responsiveness to tyrosine kinase inhibitors
por: Ray, Paramita, et al.
Publicado: (2016) -
A novel reporter for real-time, quantitative imaging of AKT-directed K63-poly-ubiquitination in living cells
por: Nyati, Shyam, et al.
Publicado: (2018) -
Novel molecular imaging platform for monitoring oncological kinases
por: Nyati, Shyam, et al.
Publicado: (2010)