Pharmacological Targeting SHP-1-STAT3 Signaling Is a Promising Therapeutic Approach for the Treatment of Colorectal Cancer()()

STAT3 activation is associated with poor prognosis in human colorectal cancer (CRC). Our previous data demonstrated that regorafenib (Stivarga) is a pharmacological agonist of SH2 domain-containing phosphatase 1 (SHP-1) that enhances SHP-1 activity and induces apoptosis by targeting STAT3 signals in...

Descripción completa

Detalles Bibliográficos
Autores principales: Fan, Li-Ching, Teng, Hao-Wei, Shiau, Chung-Wai, Tai, Wei-Tien, Hung, Man-Hsin, Yang, Shung-Haur, Jiang, Jeng-Kai, Chen, Kuen-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611073/
https://www.ncbi.nlm.nih.gov/pubmed/26476076
http://dx.doi.org/10.1016/j.neo.2015.08.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611073/
https://www.ncbi.nlm.nih.gov/pubmed/26476076
http://dx.doi.org/10.1016/j.neo.2015.08.007

Ejemplares similares