PGC-1α Silencing Compounds the Perturbation of Mitochondrial Function Caused by Mutant SOD1 in Skeletal Muscle of ALS Mouse Model

Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disease causing death of motor neurons. This study investigated the roles of energy metabolism in the pathogenesis of ALS in the SOD1(G93A) transgenic mouse model. Control and SOD1(G93A) mice were administered with shcontrol or shPGC-...

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Detalles Bibliográficos
Autores principales: Qi, Yan, Yin, Xiang, Wang, Shuyu, Jiang, Hongquan, Wang, Xudong, Ren, Ming, Su, Xiang-ping, Lei, Shi, Feng, Honglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611176/
https://www.ncbi.nlm.nih.gov/pubmed/26539112
http://dx.doi.org/10.3389/fnagi.2015.00204

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611176/
https://www.ncbi.nlm.nih.gov/pubmed/26539112
http://dx.doi.org/10.3389/fnagi.2015.00204

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