Cargando…

Tissue-specific deregulation of selected HDACs characterizes ALS progression in mouse models: pharmacological characterization of SIRT1 and SIRT2 pathways

Acetylation homeostasis is thought to play a role in amyotrophic lateral sclerosis, and treatment with inhibitors of histone deacetylases has been considered a potential and attractive therapeutic approach, despite the lack of a thorough study of this class of proteins. In this study, we have consid...

Descripción completa

Detalles Bibliográficos
Autores principales:	Valle, C, Salvatori, I, Gerbino, V, Rossi, S, Palamiuc, L, René, F, Carrì, M T
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611720/ https://www.ncbi.nlm.nih.gov/pubmed/24946089 http://dx.doi.org/10.1038/cddis.2014.247

Ejemplares similares

Further Characterization of HDAC and SIRT Gene Expression Patterns in Pancreatic Cancer and Their Relation to Disease Outcome
por: Ouaïssi, Mehdi, et al.
Publicado: (2014)

SIRT3 deregulation is linked to mitochondrial dysfunction in Alzheimer's disease
por: Lee, Junghee, et al.
Publicado: (2017)

Metabolic Characterization of a Sirt5 deficient mouse model
por: Yu, Jiujiu, et al.
Publicado: (2013)

Methylglyoxal-Dependent Glycative Stress and Deregulation of SIRT1 Functional Network in the Ovary of PCOS Mice
por: Di Emidio, Giovanna, et al.
Publicado: (2020)

Sirtuins’ Deregulation in Bladder Cancer: SIRT7 Is Implicated in Tumor Progression through Epithelial to Mesenchymal Transition Promotion
por: Monteiro-Reis, Sara, et al.
Publicado: (2020)

Interactomic and Pharmacological Insights on Human Sirt-1
por: Sharma, Ankush, et al.
Publicado: (2012)

Targeting the deacetylase SIRT6 unveils spliceosome deregulation as exploitable vulnerability for aggressive myeloma
por: Gelli, Elisa, et al.
Publicado: (2023)

Advances in Cellular Characterization of the Sirtuin Isoform, SIRT7
por: Wu, Di, et al.
Publicado: (2018)

Characterization of physiological defects in adult SIRT6(-/-) mice
por: Peshti, Victoria, et al.
Publicado: (2017)

Catalytic-independent neuroprotection by SIRT1 is mediated through interaction with HDAC1
por: Pfister, Jason A., et al.
Publicado: (2019)

SIRT1 and SIRT2 inhibition impairs pediatric soft tissue sarcoma growth
por: Ma, L, et al.
Publicado: (2014)

Metabolic Effects of Known and Novel HDAC and SIRT Inhibitors in Glioblastomas Independently or Combined with Temozolomide
por: Cuperlovic-Culf, Miroslava, et al.
Publicado: (2014)

Mitotic H3K9ac is controlled by phase-specific activity of HDAC2, HDAC3, and SIRT1
por: Gandhi, Shashi, et al.
Publicado: (2022)

RASSF1A Regulates Spindle Organization by Modulating Tubulin Acetylation via SIRT2 and HDAC6 in Mouse Oocytes
por: Jeon, Hyuk-Joon, et al.
Publicado: (2020)

SIRT1 and SIRT2: emerging targets in neurodegeneration
por: Donmez, Gizem, et al.
Publicado: (2013)

Beneficial and Sexually Dimorphic Response to Combined HDAC Inhibitor Valproate and AMPK/SIRT1 Pathway Activator Resveratrol in the Treatment of ALS Mice
por: Bankole, Oluwamolakun, et al.
Publicado: (2022)

Sirtes : 1932-1944
por: Reyes, Alfonso, 1889-1959
Publicado: (1949)

The Effect of Antiretroviral Therapy on SIRT1, SIRT3 and SIRT6 Expression in HIV-Infected Patients
por: Jurkowska, Karolina, et al.
Publicado: (2022)

SirT1 Regulates Adipose Tissue Inflammation
por: Gillum, Matthew P., et al.
Publicado: (2011)

SIRT in 2025
por: Ponziani, Francesca Romana, et al.
Publicado: (2022)

‘SIRT8’ expressed in thyroid cancer is actually SIRT7
por: Frye, R
Publicado: (2002)

Sirt7 promotes adipogenesis by binding to and inhibiting Sirt1
por: Bober, Eva, et al.
Publicado: (2012)

SIRT1 and SIRT2 Activity Control in Neurodegenerative Diseases
por: Manjula, Ramu, et al.
Publicado: (2021)

Hypothalamic Actions of SIRT1 and SIRT6 on Energy Balance
por: Quiñones, Mar, et al.
Publicado: (2021)

Cooperative effects of SIRT1 and SIRT2 on APP acetylation
por: Li, Na, et al.
Publicado: (2023)

Abnormal expression of SIRTs in psoriasis: Decreased expression of SIRT 1-5 and increased expression of SIRT 6 and 7
por: Fan, Xiaojing, et al.
Publicado: (2019)

The SIRT3 and SIRT6 Promote Prostate Cancer Progression by Inhibiting Necroptosis-Mediated Innate Immune Response
por: Fu, Weiwei, et al.
Publicado: (2020)

PGC-1α Promotes Ureagenesis in Mouse Periportal Hepatocytes through SIRT3 and SIRT5 in Response to Glucagon
por: Li, Lulu, et al.
Publicado: (2016)

Expression of SIRT1 and SIRT3 varies according to age in mice
por: Kwon, Youngho, et al.
Publicado: (2015)

SIRT1 accelerates the progression of activity-based anorexia
por: Robinette, Timothy M., et al.
Publicado: (2020)

Sirt6 attenuates chondrocyte senescence and osteoarthritis progression
por: Ji, Ming-liang, et al.
Publicado: (2022)

Combined SIRT3 and SIRT5 deletion is associated with inner retinal dysfunction in a mouse model of type 1 diabetes
por: Lin, Jonathan B., et al.
Publicado: (2019)

Sirt1 and the Mitochondria
por: Tang, Bor Luen
Publicado: (2016)

O-GlcNAcylation and stablization of SIRT7 promote pancreatic cancer progression by blocking the SIRT7-REGγ interaction
por: He, Xiaoman, et al.
Publicado: (2022)

HDAC8 cooperates with SMAD3/4 complex to suppress SIRT7 and promote cell survival and migration
por: Tang, Xiaolong, et al.
Publicado: (2020)

SIRT1 and SIRT2 Modulators: Potential Anti-Inflammatory Treatment for Depression?
por: Zhang, Yuqing, et al.
Publicado: (2021)

EFFECT OF L-VALINE TREATMENT ON SIRTUIN (SIRT1 AND SIRT2) ISOFORMS
por: Sharma, Shakshi, et al.
Publicado: (2022)

Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells
por: Iachettini, Sara, et al.
Publicado: (2018)

Design, Synthesis and Pharmacological Evaluation of Naphthofuran Derivatives as Potent SIRT1 Activators
por: Gao, Jian, et al.
Publicado: (2021)

Reversible modulation of SIRT1 activity in a mouse strain
por: Clark-Knowles, Katherine V., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_9m9uthl4jvrvej0vavoqpc0n2j