Aβ(1–42) reduces P-glycoprotein in the blood–brain barrier through RAGE–NF-κB signaling

The reduced clearance of amyloid-β peptide (Aβ) from the brain partly accounts for the neurotoxic accumulation of Aβ in Alzheimer's disease (AD). Recently, it has been suggested that P-glycoprotein (P-gp), which is an efflux transporter expressed on the luminal membrane of the brain capillary e...

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Detalles Bibliográficos
Autores principales: Park, R, Kook, S-Y, Park, J-C, Mook-Jung, I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611731/
https://www.ncbi.nlm.nih.gov/pubmed/24967961
http://dx.doi.org/10.1038/cddis.2014.258

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611731/
https://www.ncbi.nlm.nih.gov/pubmed/24967961
http://dx.doi.org/10.1038/cddis.2014.258

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