Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor–TRAF6 signaling

TRAF-interacting protein with forkhead-associated domain B (TIFAB) is a haploinsufficient gene in del(5q) myelodysplastic syndrome (MDS). Deletion of Tifab results in progressive bone marrow (BM) and blood defects, including skewed hematopoietic stem/progenitor cell (HSPC) proportions and altered my...

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Detalles Bibliográficos
Autores principales: Varney, Melinda E., Niederkorn, Madeline, Konno, Hiroyasu, Matsumura, Takayuki, Gohda, Jin, Yoshida, Nobuaki, Akiyama, Taishin, Christie, Susanne, Fang, Jing, Miller, David, Jerez, Andres, Karsan, Aly, Maciejewski, Jaroslaw P., Meetei, Ruhikanta A., Inoue, Jun-ichiro, Starczynowski, Daniel T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612089/
https://www.ncbi.nlm.nih.gov/pubmed/26458771
http://dx.doi.org/10.1084/jem.20141898

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612089/
https://www.ncbi.nlm.nih.gov/pubmed/26458771
http://dx.doi.org/10.1084/jem.20141898

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