CCR4 promotes medullary entry and thymocyte–dendritic cell interactions required for central tolerance

Autoimmunity results from a breakdown in central or peripheral tolerance. To establish central tolerance, developing T cells must enter the thymic medulla, where they scan antigen-presenting cells (APCs) displaying a diverse array of autoantigens. If a thymocyte is activated by a self-antigen, the c...

Descripción completa

Detalles Bibliográficos
Autores principales: Hu, Zicheng, Lancaster, Jessica N., Sasiponganan, Chayanit, Ehrlich, Lauren I.R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612092/
https://www.ncbi.nlm.nih.gov/pubmed/26417005
http://dx.doi.org/10.1084/jem.20150178

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612092/
https://www.ncbi.nlm.nih.gov/pubmed/26417005
http://dx.doi.org/10.1084/jem.20150178

Ejemplares similares