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CCR4 promotes medullary entry and thymocyte–dendritic cell interactions required for central tolerance

Autoimmunity results from a breakdown in central or peripheral tolerance. To establish central tolerance, developing T cells must enter the thymic medulla, where they scan antigen-presenting cells (APCs) displaying a diverse array of autoantigens. If a thymocyte is activated by a self-antigen, the c...

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Detalles Bibliográficos
Autores principales:	Hu, Zicheng, Lancaster, Jessica N., Sasiponganan, Chayanit, Ehrlich, Lauren I.R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612092/ https://www.ncbi.nlm.nih.gov/pubmed/26417005 http://dx.doi.org/10.1084/jem.20150178

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