Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms

The cohesin complex (consisting of Rad21, Smc1a, Smc3, and Stag2 proteins) is critically important for proper sister chromatid separation during mitosis. Mutations in the cohesin complex were recently identified in a variety of human malignancies including acute myeloid leukemia (AML). To address th...

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Detalles Bibliográficos
Autores principales: Mullenders, Jasper, Aranda-Orgilles, Beatriz, Lhoumaud, Priscillia, Keller, Matthew, Pae, Juhee, Wang, Kun, Kayembe, Clarisse, Rocha, Pedro P., Raviram, Ramya, Gong, Yixiao, Premsrirut, Prem K., Tsirigos, Aristotelis, Bonneau, Richard, Skok, Jane A., Cimmino, Luisa, Hoehn, Daniela, Aifantis, Iannis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612095/
https://www.ncbi.nlm.nih.gov/pubmed/26438359
http://dx.doi.org/10.1084/jem.20151323

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612095/
https://www.ncbi.nlm.nih.gov/pubmed/26438359
http://dx.doi.org/10.1084/jem.20151323

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