Endogenous vs Exogenous Allosteric Modulators in GPCRs: A dispute for shuttling CB(1) among different membrane microenvironments

A Cannabinoid Receptor 1 (CB(1)) binding site for the selective allosteric modulator ORG27569 is here identified through an integrate approach of consensus pocket prediction, mutagenesis studies and Mass Spectrometry. This unprecedented ORG27569 pocket presents the structural features of a Cholester...

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Detalles Bibliográficos
Autores principales: Stornaiuolo, Mariano, Bruno, Agostino, Botta, Lorenzo, Regina, Giuseppe La, Cosconati, Sandro, Silvestri, Romano, Marinelli, Luciana, Novellino, Ettore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612305/
https://www.ncbi.nlm.nih.gov/pubmed/26482099
http://dx.doi.org/10.1038/srep15453

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612305/
https://www.ncbi.nlm.nih.gov/pubmed/26482099
http://dx.doi.org/10.1038/srep15453

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